Safety Pharmacology

Safety Pharmacology is designed to investigate adverse effects of test articles on vital function in mammalian species.

Frontier designs Safety Pharmacology studies to determine the response of potential adverse effects.

Cardiovascular System

Conscious/unconscious Animals (telemetry or manual)

• Blood pressure
• Heart rat
• Electrocardiogram (including QTc)

Developmental and Reproductive Toxicology (DART)

Our DART Toxicity studies are designed to meet the specifications of the highest scientific and regulatory standards.  The studies are conducted in an AAALAC International-accredited facility according to U.S FDA GLP and other national and international guidelines  Additionally, the studies comply with pertinent regulatory formats, including ICH and OECD.

Frontier’s on-going training programs for our professional and technical staff ensure that our capabilities reflect the latest in scientific and regulatory thought.

• Fertility (Segment 1)
• Embryo-fetal Development (Teratology – Segment II)
• Perinatal and Postnatal Development, including Maternal Function (Segment III)

Genetic Toxicology

• Salmonella/Mammalian Microsome Assay (AMES)
• TK Gene Mutation Assay
• Mouse Marrow Micronucleus Test