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Preclinical Services
Toxicology Services
Frontier BioSciences offers a comprehensive range of toxicology studies to support clinical trials and marketing approvals of pharmaceuticals, biotechnology and Traditional Chinese Medicine products.
Single Dose Toxicology
Repeat Dose Toxicology
Safety Pharmacology
Developmental and Reproductive Toxicology
Genotoxicity
Local Tolerance
Carcinogenicity
TK/PK
Immunogenicity
PK/TK/ADME
Frontier BioSciences' scientists are recognized experts in PK, bioavailability, bio-distribution, and bioequivalence analyses for new or experimental drugs. Our staff has investigated a wide variety of small molecule drugs and protein biopharmaceuticals in a variety of animal models using standard delivery methods. Our Bioanalytical services are comprised of experienced chemists using the latest instrumentation for the determination of drug concentrations and identification of metabolites.
in vivo PK/ADME
in vitro ADME
Bioavailability
Bioequivalence
Biodistribution
Bioanalytical services
Clinical Pathology / Histopathology
Our state-of-the-art Clinical Pathology laboratory is equipped with the technology necessary to perform full scale hematology, clinical chemistry, urinalysis, coagulation and osmolarity analysis.
Our Histology laboratory staff is utilizing the most highly-advanced technologies, including standard staining, immunohistochemistry, in situ hybridization, electron microscopy, cell proliferation assays, and apoptosis evaluations.
Animal Disease Models
The use of animals as models for human disease has been indispensable in understanding the causes, biology, and prevention of disease. With our clients and research collaborators, our experienced scientists at Frontier Biosciences are continually identifying and developing new animal models to evaluate pathogenic mechanisms, diagnostic and therapeutic procedures, nutrition and metabolic disease, and the efficacy of novel drug development. These models are used with the intention of discovering and quantifying the impact of a treatment, whether this is to cure a disease, or to assess toxicity of a chemical compound.
The following disease models have been developed at Frontier BioSciences:
Morphine Addition in Rhesus
Parkinson's Disease in Rhesus
Kidney and Liver Transplant in Rhesus and Swine
Radiation Protection Rhesus Model
Female Infertility Therapy in Rhesus
Heart Failure in Rhesus
Aging Evaluation in Rhesus
Type II Diabetes (B Cell Damage) in Rats
Obesity in Rats
Anti-Tumor in Nude Mice
Inflammatory in Rats
Animal Species
Rodents
- Sprague-Dawley rat
- Wistar rat
- Kunming mice
- NIH mice
- Balb7-1C mice
Rabbits
- Japanese
- New Zealand White
Canines
- Beagle dogs
Swine
- Mini-pigs
Non-human primates
- Rhesus Macaque
- Cynomolgus Macaque
Guinea Pigs |
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